A human genome editing–based MLL::AF4 ALL model recapitulates key cellular and molecular leukemogenic features

Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome

Early human lung immune cell development and its role in epithelial cell fate

Human fetal brain self-organizes into long-term expanding organoids

Kaufman Atlas of Mouse Development

A new section of the HDBR Atlas eHistology viewer has been created to host the Kaufman Atlas of Mouse Development

Hunting for the elusive target antigen in gestational alloimmune liver disease (GALD)

Fetal development of the human amygdala

HDBR Out and About

Bio-Techne School of RNAscope Conference 2024

RET enhancer haplotype-dependent remodeling of the human fetal gut development program

Integrative analysis of transcriptome dynamics during human craniofacial development identifies candidate disease genes

Development of the arterial roots and ventricular outflow tracts

Single-Nuclei RNA Sequencing of 5 Regions of the Human Prenatal Brain Implicates Developing Neuron Populations in Genetic Risk for Schizophrenia

An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development

HDBR image featured on the front cover of March 2024 Journal of Anatomy

HDBR Out and About

Histology and Pathology Interest group (HAPI), with Aragorn Jones of HDBR

Granulocyte-colony stimulating factor does not prevent in vitro cisplatin-induced germ cell reduction in immature human and mouse testis

Early Regional Patterning in the Human Prefrontal Cortex Revealed by Laminar Dynamics of Deep Projection Neuron Markers

Single-cell RNA sequencing reveals transcriptional changes of human choroidal and retinal pigment epithelium cells during fetal development, in healthy adult and intermediate age-related macular degeneration

Differential effects of SARS-CoV-2 variants on central nervous system cells and blood-brain barrier functions

Single cell-guided prenatal derivation of primary epithelial organoids from the human amniotic and tracheal fluids

Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease

Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies

Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves

Animated overviews of embryology

A new section of the HDBR Atlas has been created to host animated overviews of embryology

Caudal Fgfr1 disruption produces localised spinal mis-patterning and a terminal myelocystocele-like phenotype in mice

Hydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic cultures

HDBR Out and About

Joint Newcastle University and Northumbria University TechNet Event

Newcastle scientists recognised in national British Heart Foundation image competition

In utero origin of myelofibrosis presenting in adult monozygotic twins

Genetic risk of osteoarthritis operates during human skeletogenesis

Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia

Expanding the HPSE2 Genotypic Spectrum in Urofacial Syndrome, A Disease Featuring a Peripheral Neuropathy of the Urinary Bladder

Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative Disorders

Integrated role of human thymic stromal cells in hematopoietic stem cell extravasation

Expression patterns of ciliopathy genes ARL3 and CEP120 reveal roles in multisystem development

The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling

Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution

Dystrophin deficiency affects human astrocyte properties and response to damage

High resolution transverse sections for each stage CS10 to CS23

Now available

HDBR Out and About

European Developmental Biology Congress 2023 (EDBC 2023)

HDBR Scientist, Jasmin Turner, wins HDBI research talk prize!

Using single-cell multi-omics screening of human fetal pancreas to identify novel players in human beta cell development

Atrial Septal Defect (ASD) associated long non-coding RNA STX18-AS1 maintains time-course of in vitro cardiomyocyte differentiation

Developmental dynamics of the neural crest–mesenchymal axis in creating the thymic microenvironment

Single-cell RNA sequencing reveals transcriptional changes of human choroidal and retinal pigment epithelium cells during fetal development, in healthy adult and intermediate age-related macular degeneration

Failure of human rhombic lip differentiation underlies medulloblastoma formation

Single-cell transcriptomic and spatial landscapes of the developing human pancreas

HDBR New Ethics Approval

An integrated single-cell analysis of human adrenal cortex development

HDBR Out and About

Human Developmental Biology Initiative June 2023

HDBR - Winners of bake your research 2023

HDBR Out and About

Centre for Biomedical Engineering Summer Meeting. The Core, Newcastle Helix

A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis

Unified rhombic lip origins of group 3 and group 4 medulloblastoma

Haemorrhage of human foetal cortex associated with SARS-CoV-2 infection

Visualization of macrophage subsets in the development of the fetal human inner ear

Interactive 3D brain models now available

Interactive 3D embryo models.

CD34+CD19−CD22+ B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies

Recessive PRDM13 mutations cause fatal perinatal brainstem dysfunction with cerebellar hypoplasia and disrupt Purkinje cell differentiation

NEW: SOX11 variants cause a neurodevelopmental disorder with infrequent ocular malformations and hypogonadotropic hypogonadism and with distinct DNA methylation profile

HDBR @ Genetics Society Genetics of Reproduction Conference

Patient Experience Survey Results

Mapping the developing human cardiac endothelium at single-cell resolution identifies MECOM as a regulator of arteriovenous gene expression

HDBR @ Organoid Research Day

Tyramide signal amplification coupled with multiple immunolabeling and RNAScope in situ hybridization in formaldehyde-fixed paraffin-embedded human fetal brain

Single-cell roadmap of human gonadal development

Interactive Heart Models

Cells of the human intestinal tract mapped across space and time

Development of a physiological model of human middle ear epithelium

HDBR Abnormal Fetal Samples Exome Sequencing Data

The need for a standard for informed consent for collection of human fetal material

Featured resource: the Node (The Company of Biologists)

Human Developmental Biology Resource (HDBR) Atlas

CS16 Interactive Heart Reconstruction

Rescuing human fetal tissue research in the United States: A call for additional regulatory reform

A roadmap for the Human Developmental Cell Atlas

ZSWIM7 Is Associated With Human Female Meiosis and Familial Primary Ovarian Insufficiency

Protein expression in the developing spinal cord

Interactive models of early heart development

HDBR Publications

Image Data Resource - update

Second dataset uploaded to the Image Data Resource

HDBR Atlas – digital downloads.

Spatial and cell type transcriptional landscape of human cerebellar development

Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface

Therapeutic Potential of Niche-Specific Mesenchymal Stromal Cells for Spinal Cord Injury Repair

Single-cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic programme with human-specific features.

Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis.

Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B cell acute lymphoblastic leukemia.

HDBR Atlas – Gene expression in the developing spinal cord

Gene Expression in the Developing Spinal Cord

Msx1 deficiency interacts with hypoxia and induces a morphogenetic regulation during mouse lip development

Gene expression in the developing eye

Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset

HDBR gene expression data now available in the Image Data Resource

Identification of a Primary Stroma and Novel Endothelial Cell Projections in the Developing Human Cornea

Selective Expression of Nicotinic Receptor Sub-unit mRNA in Early Human Fetal Forebrain